| Subject: |
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Book on anti-tumour immunity |
| Name: |
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Ivan Bubanovic |
| Date Posted: |
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Sep 10, 05 - 4:28 AM |
| Email: |
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ibubanovic@yahoo.com |
| Website: |
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http://www.geocities.com/ibubanovic |
| Message: |
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Title of the book: Origin of anti-tumor immunity failure in mammals by Dr. Ivan Bubanovic
Publisher: Kluwer/Springer, July 2004
The history of science has shown the majority of hypotheses to be wrong. Sharp scientific criticism and strictly controlled experimental studies reject most of the hypotheses, leaving behind only a small number of assumptions and ideas. Nevertheless, each logical assumption should have its rightful place on the scientific ¡battlefield¡¨ supposed to assess its validity and determine its final fate. Even when a hypothesis is wrong, it still finds its place in the entire efforts of the humankind towards attaining the scientific truth. Namely, the wrong hypotheses serve largely to illuminate the way towards the correct ones or, at least, to show which way not to follow. Correct or not, ideas and hypotheses are necessary for the progress of science. They epitomize the efforts of human thought to elucidate nature without experimental verification and in the circumstances of scant data availability. Finally, hypotheses and ideas represent a symbiotic creation of our knowledge and imagination, the two most impressive appearances in the evolution of humans.
It is thoroughly unknown whether Charles Darwin was indeed familiar with the phenomenon of similarity between microcosm and macrocosm claimed by many philosophers and physicists to be convincing and fascinating. Whatever his knowledge might have been in this regard, the possibility that Darwin¡¦s approach to defining the phenomena in biology is applicable to both planetary and cellular levels is fairly real. Namely, many physiological and pathological phenomena like those found in immunology and oncology, such as various forms of immune tolerance and immunomodulation, clonal selection of immune and tumor cells, modification of subset relationships between immune cells in tissues and organs, rest on the basic postulates of Darwinism, i.e. randomness of change, negative and positive selection, set-up of ecological niches, and the like.
The body of any animal can be viewed as a society or ¡§ecosystem¡¨ whose individual members are cells, reproducing by cell division and organized into collaborative assemblies or tissues. In this ¡§ecosystem¡¨, the cells are born, live and die under various forms of selection pressure like territorial limitation, population size, source of nutrients provided, infectious agents, etc. The body is a highly organized society of cells whose main task is the maintenance of homeostasis of the whole organism. The failure of control mechanisms which make the cell the unit of society, marking the beginning of its ¡§asocial¡¨ behaviour, is most frequently a malignant alteration. This process is not abrupt, nor is it based on the single event. It is, rather, a long-term process characterized mainly by mutation, competition and natural selection operating within the population of cells. The basic mechanisms controlling the cell sociability represent the first defence line against the altered cells, while the second line of defence is supposed to be made up of the immune system cells. Speaking in Darwinian terms, within the ¡§ecosystem¡¨ of organism, cells of the immune system operate as ¡§predators¡¨ of the altered and mutated cells or cells infected by the intracellular parasites.
The biological phenomena whose mechanisms are, at present, explored and largely understood, certainly had their own evolution. Searching for the origin and details of the evolution of ¡§advanced solutions¡¨ as well as selection pressures that might justify their emergence and existence, we often fail to see that many such phenomena are, in fact, co-evolutionary by-products of ¡§evolutionary innovations¡¨. In other words, the evolutionary emergence of ¡§advanced solutions¡¨ is sometimes, if not always, accompanied by certain by-products and by the co-evolution of compensatory mechanisms acting as a counterbalance to these.
An example of the evolution of ¡§advanced solutions¡¨ is the evolution of adaptive immunity, and co-evolution of auto-immunity and alloimmunity. Alongside with the diversification of the mechanisms of adaptive immunity, auto-immunity and alloimmunity gain attribute of the evolutionary by-products and become sources of selection pressure. To that effect, alloimmunity could be a source of very strong selection pressure in mammals, simply because it is directly connected with the reproductive efficacy. At the same time, new forms of selection pressure that are connected with adaptive immunity gave rise to new mechanisms controlling killer machinery of the immune system. Finally, the last in a line of by-products in the processes of evolutionary ¡§modelling¡¨ and ¡§re-modelling¡¨ of vertebrate immune system can be called the failure of anti-tumor immunity.
There is now much evidence that tumors can be immunogenic. Tumor cells very often express antigens in a form recognizabl |
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